Brain , Imp - Sensitive Glucose - 1 , 6 - Bisphosphatase
نویسندگان
چکیده
MAMMALIAN PHOSPHOMANNOMUTASE 1 (PMM1) IS BRAIN, IMP-SENSITIVE GLUCOSE-1,6-BISPHOSPHATASE Maria Veiga-da-Cunha, Wendy Vleugels, Pushpa Maliekal, Gert Matthijs and Emile Van Schaftingen Laboratory of Physiological Chemistry, de Duve Institute and Université Catholique de Louvain, Avenue Hippocrate 75, B-1200 Brussels, Belgium; Molecular Diagnostic Laboratory, Center for Human Genetics, University of Leuven, Belgium. Running head : PMM1 is brain glucose-1,6-bisphosphatase Address correspondence to: Maria Veiga-da-Cunha, Groupe de Recherches Métaboliques, de Duve Institute, 75, av. Hippocrate, B-1200 Brussels, BELGIUM. Tel. 32 (0)2 764 75 65. Fax: 32 (0)2 764 75 98 ; E-mail: [email protected]
منابع مشابه
Overexpression of 6-phosphofructo-2-kinase/fructose-2, 6-bisphosphatase in mouse liver lowers blood glucose by suppressing hepatic glucose production.
Hepatic 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase is an important regulatory enzyme of glucose metabolism. By controlling the level of fructose-2,6-bisphosphate, an allosteric activator of the glycolytic enzyme 6-phosphofructo-1-kinase and an inhibitor of the gluconeogenic enzyme fructose-1,6-bisphosphatase, 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase regulates hepatic gluco...
متن کاملThe contributions of glucokinase and phosphofructokinase-2/fructose bisphosphatase-2 to the elevated glycolysis in hepatocytes from Zucker fa/fa rats
Abbreviations Ad, adenoviral vector; GKRP, glucokinase regulatory protein; fructose 2,6-P2, fructose-2,6-bisphosphate; glucose 6-P, glucose 6-phosphate; N/C, nuclear / cytoplasmic ratio; PFK2, 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase; PFK2-M, PFK2-S32A/H258A; PFK2-W, wild-type PFK2. Page 1 of 31 Articles in PresS. Am J Physiol Regul Integr Comp Physiol (June 6, 2007). doi:10.1152/aj...
متن کاملCerebral Gluconeogenesis and Diseases
The gluconeogenesis pathway, which has been known to normally present in the liver, kidney, intestine, or muscle, has four irreversible steps catalyzed by the enzymes: pyruvate carboxylase, phosphoenolpyruvate carboxykinase, fructose 1,6-bisphosphatase, and glucose 6-phosphatase. Studies have also demonstrated evidence that gluconeogenesis exists in brain astrocytes but no convincing data have ...
متن کاملReduced Cytosolic Fructose-1,6-Bisphosphatase Activity Leads to Loss of O(2) Sensitivity in a Flaveria linearis Mutant.
The mutant plant of Flaveria linearis characterized by Brown et al. (Plant Physiol. 81: 212-215) was studied to determine the cause of the reduced sensitivity to O(2). Analysis of CO(2) assimilation metabolites of freeze clamped leaves revealed that both 3-phosphoglycerate and ribulose 1,5-bisphosphate were high in the mutant plant relative to F. linearis with normal O(2) sensitivity. The k(cat...
متن کاملHypoglycaemic activity of Coccinia indica and Momordica charantia
Coccinia indica leaves were extracted with 60 % ethanol, solvents were evaporated and the residue was suspended in water. This suspension was administered orally at a dose of 200 mg/kg body wt. after 18 h of fasting to normal fed and streptozotocininduced male diabetic rats (180-250 g). After 90 min the rats were killed, and blood-glucose, hepatic glucose-6-phosphatase, fructose-1,6-bisphosphat...
متن کامل